| Title | : | Antiepileptic Drug Discovery: Novel Approaches |
| Author | : | Alan Talevi |
| Language | : | en |
| Rating | : | |
| Type | : | PDF, ePub, Kindle |
| Uploaded | : | Apr 11, 2021 |
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Lacosamide has a half life of about 12–16 hours, which remains unchanged if the patients is also taking enzyme inducers. Consequently, the drug is administered twice per day at 12-hour intervals. Lacosamide is excreted renally, with 95% of the drug eliminated in the urine.
Nov 19, 2015 the brain contains millions of nerve cells called neurons. These cells are constantly communicating with each other by sending and receiving.
The most recent example of a novel peptide drug class is the group of glucagon-like peptide-1 (glp-1) agonists for the treatment of type 2 diabetes mellitus (t2dm), which reached total sales of over us$2. 6 billion in 2013, with victoza™, the most prominent member of the class, reaching blockbuster status.
Epilepsy is a serious chronic neurological disorder, generally associated with seizures, affecting all age groups.
Editor of the antiepileptic drug discovery novel approaches volume of the editor of the book biopharmaceutical processes (unlp publishing - edulp, 2016).
In an era where we have numerous new antiepileptic drugs (aeds) to the in addition, many patients are still plagued by drug-related side effects and where novel innovations to improve the lives of people with epilepsy are presente.
United states established the anticonvulsant drug development. The pipeline for the development of new aeds with novel mechanisms of action.
Uncovering novel protein biomarkers in drug discovery and development: and integrate precision medicine strategies for alzheimer's disease and epilepsy.
Sep 5, 2018 new approach to drug discovery accelerates epilepsy medicine target discovery), has the potential to predict novel targets for future drugs.
Targeting receptor proteins, such as ligand-gated ion channels and g protein-coupled receptors, has directly enabled the discovery of most drugs developed to modulate receptor signalling.
Sumoylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (sumo) proteins. The process of sumoylating proteins involves an enzymatic cascade, the first step of which entails the activation of a sumo protein through an atp-dependent process catalyzed by sumo-activating enzyme (sae).
Feb 12, 2020 misregulation of wnt signaling is common in human cancer. The development of small molecule inhibitors against the wnt receptor, frizzled.
The synaptic vesicle protein sv2a is the binding site for the antiepileptic drug levetiracetam. The novel antiepileptic drug levetiracetam (ucb l059) appears to act via a specific binding site in cns membranes.
Jan 21, 2014 a number of clinical trials are exploring novel treatments for patients with breast cancer across a variety of settings.
Jul 29, 2011 here, we established a method for drug efficacy testing with surgical specimens of brain tumors, termed “tumor explant.
Supplementary new drug applications for anti-epileptic drug fycompa® as monotherapy for partial-onset seizures, pediatric indication for partial-onset seizures accepted in china. The university of tokyo and eisai announce research collaboration for the development and drug discovery of targeted protein degradation technology.
3 microbes to man: from soils and the depths to drugs as of early 2019. 5 recent advances in development, validation, and exploitation of qsar models.
Triple quad 6500+ lc-ms/ms system features multi-component iondrive technology that pushes the boundaries of quantitation. The sensitivity, speed, and performance delivered through these technology enhancements enable you to see it all, from low mass to high mass compounds.
Dec 13, 2016 using the large collection of drug-induced gene expression data from network providing opportunities for novel antiepileptic drug discovery.
Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals. Intensification of cocrystal research efforts has been accompanied by an expansion of the potential applications where cocrystals can offer a benefit.
Watch this two-part activity discussing diagnostic and therapeutic advances in the field of childhood-onset treatment-resistant epilepsy from aes 2020.
May 22, 2017 as proof-of-concept we applied craft to epilepsy, and predicted the tyrosine kinase receptor csf1r as a novel therapeutic target for epilepsy.
Kincaid also served as senior director of drug discovery at renovis, a discovery and early stage clinical company in neurological and inflammatory diseases (acquired by evotec, ag in 2008). There he invented novel p2x7 antagonists for the treatment of inflammatory disorders and novel antagonists of p2x2/3 with potential first-in-class.
Jeffrey buchhalter, university of calgary; mary connolly, university of british columbia.
Epileptic seizures are only one manifestation of neurologic or metabolic diseases. Epileptic seizures have many causes, including a genetic predisposition for certain types of seizures, head trauma, stroke, brain tumors, alcohol or drug withdrawal, repeated episodes of metabolic insults, such as hypoglycemia, and other conditions.
Indexed in: scopus, embase, book citation index, science edition, biosis previews. “frontiers in cns drug discovery” is an ebook series devoted to publishing the latest and antiepileptic drug and estradiol neuroprotection in epil.
The discovery of b*58:01:12 adds further polymorphism of b*58:01 in taiwanese population. Two novel human leucocyte antigen (hla) class i alleles have been identified in two italian individuals. There is an association between hla-b*58:01 and allopurinol-induced adverse drug reactions in a japanese sample population.
Summary: we will design a novel microfluidic diagnostic chip as a critical component of a project title: disposable chips to measure antiepileptic drug serum.
Jan 1, 2020 significance statement padsevonil, a first-in-class antiepileptic drug candidate, targets sv2 proteins and the benzodiazepine site of gaba.
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